| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIP5K1B (190-470) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIP5K1B |
| Gene ID: |
8395 |
| Uniprot ID: |
PI51B_HUMAN |
| Immunogen Region: |
190-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 190-470 of human PIP5K1B (NP_003549.1). |
| Immunogen Sequence: |
NVLPRSMRMHFTYDLKGSTY KRRASRKEREKSNPTFKDLD FLQDMHEGLYFDTETYNALM KTLQRDCRVLESFKIMDYSL LLGIHFLDHSLKEKEEETPQ NVPDAKRTGMQKVLYSTAME SIQGPGKSGDGIITENPDTM GGIPAKSHRGEKLLLFMGII DILQSYRLMKKLEHSWKALV YDGDTVSVHRPSFYADRFLK FMNSRVFKKIQALKASPSKK RCNSIAALKATSQEIVSSI |
| Tissue Specificity | Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion. |
| Protein Name | Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 BetaPip5k1-BetaPtdins(4p-5-Kinase 1 BetaPhosphatidylinositol 4-Phosphate 5-Kinase Type I BetaPip5kibetaProtein Stm-7Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-201688Reactome: R-HSA-6811558 |
| Cellular Localisation | CytoplasmCytosolCell MembraneEndomembrane SystemAssociated With Membranes |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta antibodyAnti-Pip5k1-Beta antibodyAnti-Ptdins(4p-5-Kinase 1 Beta antibodyAnti-Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta antibodyAnti-Pip5kibeta antibodyAnti-Protein Stm-7 antibodyAnti-Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta antibodyAnti-PIP5K1B antibodyAnti-STM7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
