| Tissue Specificity | Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes. Detected in omental fat and subcutaneous fat tissue. |
| Function | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. |
| Protein Name | Arrestin Domain-Containing Protein 3Tbp-2-Like Inducible Membrane ProteinTlimp |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideLysosomeEndosomeEarly EndosomeAssociated With Plasma MembraneAs Well As With Endosomes And Lysosomes During Endocytosis |
| Alternative Antibody Names | Anti-Arrestin Domain-Containing Protein 3 antibodyAnti-Tbp-2-Like Inducible Membrane Protein antibodyAnti-Tlimp antibodyAnti-ARRDC3 antibodyAnti-KIAA1376 antibody |
Information sourced from Uniprot.org
