| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANKLE2 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANKLE2 |
| Gene ID: |
23141 |
| Uniprot ID: |
ANKL2_HUMAN |
| Immunogen Region: |
350-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1). |
| Immunogen Sequence: |
CRYNVMHVAAKENQASICQL TLDVLENPDFMRLMYPDDDE AMLQKRIRYVVDLYLNTPDK MGYDTPLHFACKFGNADVVN VLSSHHLIVKNSRNKYDKTP E |
| Function | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. |
| Protein Name | Ankyrin Repeat And Lem Domain-Containing Protein 2Lem Domain-Containing Protein 4 |
| Database Links | Reactome: R-HSA-2995383Reactome: R-HSA-9013404Reactome: R-HSA-9013408 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Lem Domain-Containing Protein 2 antibodyAnti-Lem Domain-Containing Protein 4 antibodyAnti-ANKLE2 antibodyAnti-KIAA0692 antibodyAnti-LEM4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
