| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AHSA1 (1-338) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AHSA1 |
| Gene ID: |
10598 |
| Uniprot ID: |
AHSA1_HUMAN |
| Immunogen Region: |
1-338 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of human AHA1 (NP_036243.1). |
| Immunogen Sequence: |
MAKWGEGDPRWIVEERADAT NVNNWHWTERDASNWSTDKL KTLFLAVQVQNEEGKCEVTE VSKLDGEASINNRKGKLIFF YEWSVKLNWTGTSKSGVQYK GHVEIPNLSDENSVDEVEIS VSLAKDEPDTNLVALMKEEG VKLLREAMGIYISTLKTEFT QGMILPTMNGESVDPVGQPA LKTEERKAKPAPSKTQARPV GVKIPTCKITLKETFLTSPE ELYRVFTTQELVQAFTHAP |
| Tissue Specificity | Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta. |
| Post Translational Modifications | Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1. |
| Function | Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. |
| Protein Name | Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1Aha1P38 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumMay Transiently Interact With The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1 antibodyAnti-Aha1 antibodyAnti-P38 antibodyAnti-AHSA1 antibodyAnti-C14orf3 antibodyAnti-HSPC322 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
