| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAM2 (476-686) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM2 |
| Gene ID: |
2515 |
| Uniprot ID: |
ADAM2_HUMAN |
| Immunogen Region: |
476-686 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 476-686 of human ADAM2 (Q99965). |
| Immunogen Sequence: |
PCGLNQWICIDGVCMSGDKQ CTDTFGKEVEFGPSECYSHL NSKTDVSGNCGISDSGYTQC EADNLQCGKLICKYVGKFLL QIPRATIIYANISGHLCIAV EFASDHADSQKMWIKDGTSC GSNKVCRNQRCVSSSYLGYD CTTDKCNDRGVCNNKKHCHC SASYLPPDCSVQSDLWPGGS IDSGNFPPVAIPARLPERRY IENIYHSKPMR |
| Tissue Specificity | Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues. |
| Post Translational Modifications | The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa. |
| Function | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 2Adam 2Cancer/Testis Antigen 15Ct15Fertilin Subunit BetaPh-30Ph30Ph30-Beta |
| Database Links | Reactome: R-HSA-2534343 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 2 antibodyAnti-Adam 2 antibodyAnti-Cancer/Testis Antigen 15 antibodyAnti-Ct15 antibodyAnti-Fertilin Subunit Beta antibodyAnti-Ph-30 antibodyAnti-Ph30 antibodyAnti-Ph30-Beta antibodyAnti-ADAM2 antibodyAnti-FTNB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
