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Synaptotagmin 1 Blocking Peptide peptide (STJ504978)

Synaptotagmin 1 Blocking Peptide peptide (STJ504978)

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STJ504978-250

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Additional Info
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Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Synaptotagmin 1 Blocking Peptide is synthetically produced from the 1-60 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	SYT1
Gene ID:	6857
Uniprot ID:	SYT1_HUMAN
Immunogen Region:	1-60
Immunogen:	Synthetic peptide taken within amino acid region 1-60 on SYT1 protein.

Tissue Specificity	Expressed in melanocytes.
Post Translational Modifications	Glycosylated.
Function	Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes.
Peptide Name	Synaptotagmin-1 Synaptotagmin I Syti P65
Database Links	Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-5250958 Reactome: R-HSA-5250989 Reactome: R-HSA-6794361 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-888590
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Membrane Single-Pass Membrane Protein Secretory Vesicle Synaptic Vesicle Membrane Chromaffin Granule Membrane Cytoplasm
Alternative Peptide Names	Synaptotagmin-1 protein Synaptotagmin I protein Syti protein P65 protein SYT1 protein SVP65 protein SYT protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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