• Rat NSMASE (Neutral Sphingomyelinase) Sandwich ELISA Kit (STJE0011101)

Rat NSMASE (Neutral Sphingomyelinase) Sandwich ELISA Kit (STJE0011101)

SKU:
STJE0011101

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.068ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NSMASE Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Smpd3
Gene ID: 94338
Uniprot ID: NSMA2_RAT
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity In brain sections, it is restricted to neurons and especially prominent in large cells, including Purkinje cells, pyramidal cells, neurons of the dentate gyrus granular layer, and neurons in the pontine nuclei. Also present in the hypothalamic nuclei, neurons in the piriform cortex, and nuclei of the brainstem (at protein level). Mainly expressed in brain and jejunum. Weakly or not expressed in heart, spleen, lung, liver, kidney and testis.
Post Translational Modifications Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation.
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions.
Protein Name Sphingomyelin Phosphodiesterase 3
Confluent 3y1 Cell-Associated Protein 1
Neutral Sphingomyelinase 2
Nsmase-2
Nsmase2
Neutral Sphingomyelinase Ii
Database Links Reactome: R-RNO-1660662
Reactome: -RNO-5626978
Cellular Localisation Golgi Apparatus Membrane
Lipid-Anchor
Cell Membrane
May Localize To Detergent-Resistant Subdomains Of Golgi Membranes Of Hypothalamic Neurosecretory Neurons
Alternative ELISA Names Sphingomyelin Phosphodiesterase 3 ELISA kit
Confluent 3y1 Cell-Associated Protein 1 ELISA kit
Neutral Sphingomyelinase 2 ELISA kit
Nsmase-2 ELISA kit
Nsmase2 ELISA kit
Neutral Sphingomyelinase Ii ELISA kit
Smpd3 ELISA kit
Cca1 ELISA kit
output

Information sourced from Uniprot.org

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