| Tissue Specificity | Ubiquitous. Isoform 2: Expressed in proximal intestine, kidney and brain. |
| Post Translational Modifications | Ubiquitinated by WWP2. N-glycosylated. |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions. |
| Protein Name | Natural Resistance-Associated Macrophage Protein 2Nramp 2Divalent Cation Transporter 1Divalent Metal Transporter 1Dmt-1Solute Carrier Family 11 Member 2 |
| Database Links | Reactome: R-RNO-425410Reactome: -RNO-917937 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneLate Endosome MembraneLysosome MembraneApical Cell MembraneMitochondrion Outer MembraneExtracellular Vesicle Membrane |
| Alternative ELISA Names | Natural Resistance-Associated Macrophage Protein 2 ELISA kitNramp 2 ELISA kitDivalent Cation Transporter 1 ELISA kitDivalent Metal Transporter 1 ELISA kitDmt-1 ELISA kitSolute Carrier Family 11 Member 2 ELISA kitSlc11a2 ELISA kitDct1 ELISA kitDmt1 ELISA kitNramp2 ELISA kit |
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Information sourced from Uniprot.org
