• Rat CD14 (Cluster Of Differentiation 14) Sandwich ELISA Kit Ready-To-Use (STJE0014162)

Rat CD14 (Cluster Of Differentiation 14) Sandwich ELISA Kit Ready-To-Use (STJE0014162)

SKU:
STJE0014162

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.51ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This CD14 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Cd14
Gene ID: 60350
Uniprot ID: CD14_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected in macrophages and peripheral blood monocytes.
Post Translational Modifications
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14
Database Links Reactome: R-RNO-166020
Reactome: -RNO-5686938
Reactome: -RNO-6798695
Reactome: -RNO-936964
Reactome: -RNO-937072
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Soluble
Secreted Forms Seem To Exist
They May Arise By Cleavage Of The Gpi Anchor
Alternative ELISA Names Monocyte Differentiation Antigen Cd14 ELISA kit
Myeloid Cell-Specific Leucine-Rich Glycoprotein ELISA kit
Cd Antigen Cd14 ELISA kit
Cd14 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance