• Mouse TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012627)

Mouse TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012627)

SKU:
STJE0012627

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.108ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TLR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Tlr1
Gene ID: 21897
Uniprot ID: TLR1_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen.
Protein Name Toll-Like Receptor 1
Toll/Interleukin-1 Receptor-Like Protein
Til
Cd Antigen Cd281
Database Links Reactome: R-MMU-1461957
Reactome: -MMU-5686938
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Golgi Apparatus
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Triacylated Lipoproteins
Tlr2:Tlr1 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative ELISA Names Toll-Like Receptor 1 ELISA kit
Toll/Interleukin-1 Receptor-Like Protein ELISA kit
Til ELISA kit
Cd Antigen Cd281 ELISA kit
Tlr1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance