| Function | Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines. |
| Protein Name | Tir Domain-Containing Adapter Molecule 1Ticam-1Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon BetaTir Domain-Containing Adapter Protein Inducing Ifn-Beta |
| Database Links | Reactome: R-MMU-140534Reactome: -MMU-166166Reactome: -MMU-2562578Reactome: -MMU-936964Reactome: -MMU-937041Reactome: -MMU-937072Reactome: -MMU-975163Reactome: -MMU-9824878 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesicleAutophagosomeMitochondrionColocalizes With Ubqln1 In The AutophagosomeColocalizes In The Cytosol With Ddx1Ddx21 And Dhx36Colocalizes In The Mitochondria With Ddx1 And Poly(I:c) Rna LigandThe Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Rna Ligand Stimulation |
| Alternative Protein Names | Tir Domain-Containing Adapter Molecule 1 proteinTicam-1 proteinToll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta proteinTir Domain-Containing Adapter Protein Inducing Ifn-Beta proteinTicam1 proteinTrif protein |
Information sourced from Uniprot.org
