| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 34.6pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description: | This PP2Aa Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Ppp2r1a |
| Gene ID: | 51792 |
| Uniprot ID: | 2AAA_MOUSE |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha IsoformPp2a Subunit A Isoform Pr65-AlphaPp2a Subunit A Isoform R1-Alpha |
| Database Links | Reactome: R-MMU-113501Reactome: -MMU-1295596Reactome: -MMU-141444Reactome: -MMU-180024Reactome: -MMU-195253Reactome: -MMU-196299Reactome: -MMU-198753Reactome: -MMU-202670Reactome: -MMU-2467813Reactome: -MMU-2500257Reactome: -MMU-2565942Reactome: -MMU-2995383Reactome: -MMU-380259Reactome: -MMU-380270Reactome: -MMU-380284Reactome: -MMU-380320Reactome: -MMU-389513Reactome: -MMU-432142Reactome: -MMU-4641262Reactome: -MMU-5620912Reactome: -MMU-5663220Reactome: -MMU-5673000Reactome: -MMU-5675221Reactome: -MMU-6804757Reactome: -MMU-6811558Reactome: -MMU-68877Reactome: -MMU-69231Reactome: -MMU-69273Reactome: -MMU-8854518Reactome: -MMU-9648025Reactome: -MMU-975957 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereLateral Cell MembraneCell ProjectionDendriteCentromeric Localization Requires The Presence Of Bub1 |
| Alternative ELISA Names | Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform ELISA kitPp2a Subunit A Isoform Pr65-Alpha ELISA kitPp2a Subunit A Isoform R1-Alpha ELISA kitPpp2r1a ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
