• Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)

Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)

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STJE0017987

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 30.9pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This PP2Aa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PPP2R1A
Gene ID: 5518
Uniprot ID: 2AAA_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability.
Protein Name Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform
Medium Tumor Antigen-Associated 61 Kda Protein
Pp2a Subunit A Isoform Pr65-Alpha
Pp2a Subunit A Isoform R1-Alpha
Database Links Reactome: R-HSA-113501
Reactome: R-HSA-1295596
Reactome: R-HSA-141444
Reactome: R-HSA-163685
Reactome: R-HSA-163767
Reactome: R-HSA-180024
Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-198753
Reactome: R-HSA-202670
Reactome: R-HSA-2465910
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-2565942
Reactome: R-HSA-2995383
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-389513
Reactome: R-HSA-432142
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-5620912
Reactome: R-HSA-5663220
Reactome: R-HSA-5673000
Reactome: R-HSA-5675221
Reactome: R-HSA-6804757
Reactome: R-HSA-6811558
Reactome: R-HSA-68877
Reactome: R-HSA-69231
Reactome: R-HSA-69273
Reactome: R-HSA-8854518
Reactome: R-HSA-9634600
Reactome: R-HSA-9648025
Reactome: R-HSA-975957
Cellular Localisation Cytoplasm
Nucleus
Chromosome
Centromere
Lateral Cell Membrane
Cell Projection
Dendrite
Centromeric Localization Requires The Presence Of Bub1
Alternative ELISA Names Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform ELISA kit
Medium Tumor Antigen-Associated 61 Kda Protein ELISA kit
Pp2a Subunit A Isoform Pr65-Alpha ELISA kit
Pp2a Subunit A Isoform R1-Alpha ELISA kit
PPP2R1A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance