Mouse IP-10/CXCL10 (C-X-C Motif Chemokine 10) Antibody Pair (STJAP00522)

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STJAP00522-50
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Host: Goat/Goat
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This IP-10/CXCL10 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: Cxcl10
Gene ID: 15945
Uniprot ID: CXL10_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse IP-10/CXCL10 protien.
Detection Immunogen: Recombinant Mouse IP-10/CXCL10 protien.
Sample Type: Serum, plasma and other biological fluids
Function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
Protein Name C-X-C Motif Chemokine 10
10 Kda Interferon Gamma-Induced Protein
Gamma-Ip10
Ip-10
C7
Interferon-Gamma Induced Protein Crg-2
Small-Inducible Cytokine B10
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative Antibody Pair Names C-X-C Motif Chemokine 10 antibody pair
10 Kda Interferon Gamma-Induced Protein antibody pair
Gamma-Ip10 antibody pair
Ip-10 antibody pair
C7 antibody pair
Interferon-Gamma Induced Protein Crg-2 antibody pair
Small-Inducible Cytokine B10 antibody pair
Cxcl10 antibody pair
Crg2 antibody pair
Ifi10 antibody pair
Inp10 antibody pair
Scyb10 antibody pair

Information sourced from Uniprot.org

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