Tissue Specificity | Is highly expressed in lumbosacral and thoracolumbar dorsal root ganglion neurons. |
Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. |
Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1hVoltage-Gated Calcium Channel Subunit Alpha Cav3.2 |
Database Links | |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInteraction With Stac Increases Expression At The Cell Membrane |
Alternative ELISA Names | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1h ELISA kitVoltage-Gated Calcium Channel Subunit Alpha Cav3.2 ELISA kitCacna1h ELISA kitKiaa1120 ELISA kit |
output | |
Information sourced from Uniprot.org