• Mouse ANXA1 (Annexin A1) Sandwich ELISA Kit Ready-To-Use (STJE0013549)

Mouse ANXA1 (Annexin A1) Sandwich ELISA Kit Ready-To-Use (STJE0013549)

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STJE0013549

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.37ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This ANXA1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Anxa1
Gene ID: 16952
Uniprot ID: ANXA1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected in lung. Detected at the apical membrane of airway epithelial cells. Detected in intestinal epithelial cells. Detected in skeletal muscle. Detected in prostate. Detected in thymus (at protein level). Detected in stomach, lung, spleen, ovary and uterus, and at lower levels in kidney, thymus and heart.
Post Translational Modifications Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment. Sumoylated. Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
Function Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. Annexin Ac2-26: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
Protein Name Annexin A1
Annexin I
Annexin-1
Calpactin Ii
Calpactin-2
Chromobindin-9
Lipocortin I
Phospholipase A2 Inhibitory Protein
P35 Cleaved Into - Annexin Ac2-26
Database Links Reactome: R-MMU-416476
Reactome: -MMU-418594
Reactome: -MMU-444473
Cellular Localisation Nucleus
Cytoplasm
Cell Projection
Cilium
Basolateral Cell Membrane
Lateral Cell Membrane
Cell Membrane
Peripheral Membrane Protein
Apical Cell Membrane
Membrane
Early Endosome
Cytoplasmic Vesicle Membrane
Endosome Membrane
Secreted
Extracellular Space
Extracellular Side
Extracellular Exosome
Cytoplasmic Vesicle
Secretory Vesicle Lumen
Phagocytic Cup
Colocalizes With Actin Fibers At Phagocytic Cups
At Least In Part Via Exosomes And Other Secretory Vesicles
Detected In Exosomes And Other Extracellular Vesicles
Secretion Is Increased In Response To Wounding And Inflammation
Detected In Gelatinase Granules In Resting Neutrophils
Neutrophil Adhesion To Endothelial Cells Stimulates Secretion Via Gelatinase Granules
But Foreign Particle Phagocytosis Has No Effect
Displays Calcium-Dependent Binding To Phospholipid Membranes
Alternative ELISA Names Annexin A1 ELISA kit
Annexin I ELISA kit
Annexin-1 ELISA kit
Calpactin Ii ELISA kit
Calpactin-2 ELISA kit
Chromobindin-9 ELISA kit
Lipocortin I ELISA kit
Phospholipase A2 Inhibitory Protein ELISA kit
P35 Cleaved Into - Annexin Ac2-26 ELISA kit
Anxa1 ELISA kit
Anx1 ELISA kit
Lpc-1 ELISA kit
Lpc1 ELISA kit
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Information sourced from Uniprot.org