Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.37ng/mL |
Detection Limit: | 0.781-50ng/mL |
Short Description: | This ANXA1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | Anxa1 |
Gene ID: | 16952 |
Uniprot ID: | ANXA1_MOUSE |
Immunogen Region: | Ready-To-Use |
Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
Tissue Specificity | Detected in lung. Detected at the apical membrane of airway epithelial cells. Detected in intestinal epithelial cells. Detected in skeletal muscle. Detected in prostate. Detected in thymus (at protein level). Detected in stomach, lung, spleen, ovary and uterus, and at lower levels in kidney, thymus and heart. |
Post Translational Modifications | Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment. Sumoylated. Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26. |
Function | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. Annexin Ac2-26: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. |
Protein Name | Annexin A1 Annexin I Annexin-1 Calpactin Ii Calpactin-2 Chromobindin-9 Lipocortin I Phospholipase A2 Inhibitory Protein P35 Cleaved Into - Annexin Ac2-26 |
Database Links | Reactome: R-MMU-416476 Reactome: -MMU-418594 Reactome: -MMU-444473 |
Cellular Localisation | Nucleus Cytoplasm Cell Projection Cilium Basolateral Cell Membrane Lateral Cell Membrane Cell Membrane Peripheral Membrane Protein Apical Cell Membrane Membrane Early Endosome Cytoplasmic Vesicle Membrane Endosome Membrane Secreted Extracellular Space Extracellular Side Extracellular Exosome Cytoplasmic Vesicle Secretory Vesicle Lumen Phagocytic Cup Colocalizes With Actin Fibers At Phagocytic Cups At Least In Part Via Exosomes And Other Secretory Vesicles Detected In Exosomes And Other Extracellular Vesicles Secretion Is Increased In Response To Wounding And Inflammation Detected In Gelatinase Granules In Resting Neutrophils Neutrophil Adhesion To Endothelial Cells Stimulates Secretion Via Gelatinase Granules But Foreign Particle Phagocytosis Has No Effect Displays Calcium-Dependent Binding To Phospholipid Membranes |
Alternative ELISA Names | Annexin A1 ELISA kit Annexin I ELISA kit Annexin-1 ELISA kit Calpactin Ii ELISA kit Calpactin-2 ELISA kit Chromobindin-9 ELISA kit Lipocortin I ELISA kit Phospholipase A2 Inhibitory Protein ELISA kit P35 Cleaved Into - Annexin Ac2-26 ELISA kit Anxa1 ELISA kit Anx1 ELISA kit Lpc-1 ELISA kit Lpc1 ELISA kit |
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Information sourced from Uniprot.org