| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
3.7ng/mL |
| Detection Limit: |
9.37-600ng/mL |
| Short Description: |
This a2M Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
A2m |
| Gene ID: |
232345 |
| Uniprot ID: |
A2MG_MOUSE |
| Sample Type: |
serum, plasma, urine or other biological fluids. |
| Tissue Specificity | Expressed in uterus, mesometrial lymphoid aggregate and mammary tissue during pregnancy. Expressed in ovary, testis and kidney. Low level expression in heart. Not expressed in liver. |
| Post Translational Modifications | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-Macroglobulin-PAlpha-2-Macroglobulin |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-140837Reactome: -MMU-1474228Reactome: -MMU-8963896 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Alpha-2-Macroglobulin-P ELISA kitAlpha-2-Macroglobulin ELISA kitA2m ELISA kitA2mp ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
