| Host: |
sf9 Insect cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Ubiquitin-activating enzyme E1/UBE1/UBA1-No Tag protein was developed from sf9 insect cells and has a target region of No Tag. For use in research applications. |
| Formulation: |
20 mM Tris, 150 mM NaCl, 2 mM BetaME, 10% Glycerol |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Post Translational Modifications | ISGylated. |
| Function | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 1Protein A1s9Ubiquitin-Activating Enzyme E1 |
| Database Links | Reactome: R-HSA-8866652Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMitochondrionNucleusIsoform 1: NucleusIsoform 2: Cytoplasm |
| Alternative Protein Names | Ubiquitin-Like Modifier-Activating Enzyme 1 proteinProtein A1s9 proteinUbiquitin-Activating Enzyme E1 proteinUBA1 proteinA1S9T proteinUBE1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
