Human tPA/Tissue-type plasminogen activator/PLAT protein (Recombinant) (C-6×His) (STJP002642)

SKU:
STJP002642

£147.50 - £391.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human tPA/Tissue-type plasminogen activator/PLAT-C-6×His protein was developed from hek293 cells and has a target region of C-6×His. For use in research applications.
Formulation: Lyophilized from a 0.2 Mu m filtered solution of 20mM MES, 150mM NaCl, 0.2mM CaCl2, pH5.5.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLAT
Gene ID: 5327
Uniprot ID: TPA_HUMAN
Immunogen Region: Ser36-Pro562
Immunogen: Recombinant Human tPA/Tissue-type plasminogen activator/PLAT Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ser36-Pro562) of human tPA/Tissue-type plasminogen activator/PLAT (Accession #P00750) fu
Post Translational Modifications The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa. Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin. N-glycosylation of Asn-152.the bound oligomannosidic glycan is involved in the interaction with the mannose receptor. Characterization of O-linked glycan was studied in Bowes melanoma cell line.
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.
Protein Name Tissue-Type Plasminogen Activator
T-Pa
T-Plasminogen Activator
Tpa
Alteplase
Reteplase Cleaved Into - Tissue-Type Plasminogen Activator Chain A - Tissue-Type Plasminogen Activator Chain B
Database Links Reactome: R-HSA-186797
Reactome: R-HSA-75205
Cellular Localisation Secreted
Extracellular Space
Alternative Protein Names Tissue-Type Plasminogen Activator protein
T-Pa protein
T-Plasminogen Activator protein
Tpa protein
Alteplase protein
Reteplase Cleaved Into - Tissue-Type Plasminogen Activator Chain A - Tissue-Type Plasminogen Activator Chain B protein
PLAT protein

Information sourced from Uniprot.org

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