| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.062ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This TMPRSS4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
TMPRSS4 |
| Gene ID: |
56649 |
| Uniprot ID: |
TMPS4_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. Coexpressed with ACE2 within mature enterocytes. |
| Post Translational Modifications | Proteolytically processed.probably by an autocatalytic mechanism. |
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. |
| Protein Name | Transmembrane Protease Serine 4Channel-Activating Protease 2Caph2Membrane-Type Serine Protease 2Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTransmembrane Protease Serine 4 Catalytic Chain: SecretedActivated By Cleavage And Secreted |
| Alternative ELISA Names | Transmembrane Protease Serine 4 ELISA kitChannel-Activating Protease 2 ELISA kitCaph2 ELISA kitMembrane-Type Serine Protease 2 ELISA kitMt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain ELISA kitTMPRSS4 ELISA kitTMPRSS3 ELISA kitUNQ776 ELISA kitPRO1570 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
