| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SKP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SKP1 |
| Gene ID: | 6500 |
| Uniprot ID: | SKP1_HUMAN |
| Immunogen Region: | Met1-Lys163 |
| Immunogen: | Homo sapiens (Human) |
| Function | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'.the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | S-Phase Kinase-Associated Protein 1Cyclin-A/Cdk2-Associated Protein P19P19aOrgan Of Corti Protein 2Ocp-2Organ Of Corti Protein IiOcp-IiRna Polymerase Ii Elongation Factor-Like ProteinSiiiTranscription Elongation Factor B Polypeptide 1-LikeP19skp1 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1170546Reactome: R-HSA-174113Reactome: R-HSA-180534Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-2122947Reactome: R-HSA-2565942Reactome: R-HSA-2644606Reactome: R-HSA-2644607Reactome: R-HSA-2871837Reactome: R-HSA-2894862Reactome: R-HSA-400253Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5676590Reactome: R-HSA-5684264Reactome: R-HSA-68949Reactome: R-HSA-69231Reactome: R-HSA-8854050Reactome: R-HSA-8939902Reactome: R-HSA-8951664Reactome: R-HSA-9020702Reactome: R-HSA-917937Reactome: R-HSA-9604323Reactome: R-HSA-9708530Reactome: R-HSA-9725371Reactome: R-HSA-9762114Reactome: R-HSA-983168 |
| Alternative Protein Names | S-Phase Kinase-Associated Protein 1 proteinCyclin-A/Cdk2-Associated Protein P19 proteinP19a proteinOrgan Of Corti Protein 2 proteinOcp-2 proteinOrgan Of Corti Protein Ii proteinOcp-Ii proteinRna Polymerase Ii Elongation Factor-Like Protein proteinSiii proteinTranscription Elongation Factor B Polypeptide 1-Like proteinP19skp1 proteinSKP1 proteinEMC19 proteinOCP2 proteinSKP1A proteinTCEB1L protein |
Information sourced from Uniprot.org