Human SGMS1 protein (Recombinant) (N-His-SUMO) (STJP008972)

SKU:
STJP008972
$443.48 - $1,940.63
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SGMS1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SGMS1
Gene ID: 259230
Uniprot ID: SMS1_HUMAN
Immunogen Region: Lys2-Ala81
Immunogen: Homo sapiens (Human)
Function Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1.
Protein Name Phosphatidylcholine -Ceramide Cholinephosphotransferase 1
Medulla Oblongata-Derived Protein
Protein Mob
Sphingomyelin Synthase 1
Transmembrane Protein 23
Database Links Reactome: R-HSA-1660661
Cellular Localisation Golgi Apparatus Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Phosphatidylcholine -Ceramide Cholinephosphotransferase 1 protein
Medulla Oblongata-Derived Protein protein
Protein Mob protein
Sphingomyelin Synthase 1 protein
Transmembrane Protein 23 protein
SGMS1 protein
MOB protein
SMS1 protein
TMEM23 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP003590 Human APOA2 protein (Recombinant) (N-His-SUMO) (STJP003590) E. coli
STJP003879 Human FGF2 protein (Recombinant) (N-His-SUMO) (STJP003879) E. coli
STJP004668 Human GDNF protein (Recombinant) (N-His-SUMO) (STJP004668) E. coli
STJP007322 Human CD81 protein (Recombinant) (N-His-SUMO) (STJP007322) E. coli
STJP007330 Human HNRNPH1 protein (Recombinant) (N-His-SUMO) (STJP007330) E. coli

Related Products

!