Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.056ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description: | This SGLT1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | SLC5A1 |
Gene ID: | 6523 |
Uniprot ID: | SC5A1_HUMAN |
Immunogen Region: | Ready-To-Use |
Sample Type: | tissue homogenates or other biological fluids. |
Tissue Specificity | Expressed in intestine. Expressed in endometrial cells. |
Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
Function | Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
Protein Name | Sodium/Glucose Cotransporter 1 Na(+/Glucose Cotransporter 1 High Affinity Sodium-Glucose Cotransporter Solute Carrier Family 5 Member 1 |
Database Links | Reactome: R-HSA-189200 Reactome: R-HSA-5656364 Reactome: R-HSA-8981373 |
Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein |
Alternative ELISA Names | Sodium/Glucose Cotransporter 1 ELISA kit Na(+/Glucose Cotransporter 1 ELISA kit High Affinity Sodium-Glucose Cotransporter ELISA kit Solute Carrier Family 5 Member 1 ELISA kit SLC5A1 ELISA kit NAGT ELISA kit SGLT1 ELISA kit |
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Information sourced from Uniprot.org