• Human SGLT1 (Sodium/Glucose Cotransporter 1) Sandwich ELISA Kit (STJE0012136)

Human SGLT1 (Sodium/Glucose Cotransporter 1) Sandwich ELISA Kit (STJE0012136)

SKU:
STJE0012136

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SGLT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC5A1
Gene ID: 6523
Uniprot ID: SC5A1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in intestine. Expressed in endometrial cells.
Post Translational Modifications N-glycosylation is not necessary for the cotransporter function.
Function Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Protein Name Sodium/Glucose Cotransporter 1
Na(+/Glucose Cotransporter 1
High Affinity Sodium-Glucose Cotransporter
Solute Carrier Family 5 Member 1
Database Links Reactome: R-HSA-189200
Reactome: R-HSA-5656364
Reactome: R-HSA-8981373
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Sodium/Glucose Cotransporter 1 ELISA kit
Na(+/Glucose Cotransporter 1 ELISA kit
High Affinity Sodium-Glucose Cotransporter ELISA kit
Solute Carrier Family 5 Member 1 ELISA kit
SLC5A1 ELISA kit
NAGT ELISA kit
SGLT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance