| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human R-spondin-3-C-Fc & His protein was developed from hek293 cells and has a target region of C-Fc & His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.2 Mu m filtered solution of 20 mM PB, 150 mM NaCl, pH7.2. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RSPO3 |
| Gene ID: |
84870 |
| Uniprot ID: |
RSPO3_HUMAN |
| Immunogen Region: |
Gln22-His272 |
| Immunogen: |
Recombinant Human R-spondin-3 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Gln22-His272) of human R-spondin-3/RSPO3 (Accession #Q9BXY4) fused with an Fc, 6×His tag at the C-terminus. |
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3. |
| Protein Name | R-Spondin-3Protein With Tsp Type-1 RepeatHpwtsrRoof Plate-Specific Spondin-3Hrspo3Thrombospondin Type-1 Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-4641263Reactome: R-HSA-8939256 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | R-Spondin-3 proteinProtein With Tsp Type-1 Repeat proteinHpwtsr proteinRoof Plate-Specific Spondin-3 proteinHrspo3 proteinThrombospondin Type-1 Domain-Containing Protein 2 proteinRSPO3 proteinPWTSR proteinTHSD2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
