| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Thrombopoietin R/MPL-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Immobilized Human c-MPL, His Tag at 0.2 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 9.1ng/ml determined by ELISA. |
| Gene Symbol: |
MPL |
| Gene ID: |
4352 |
| Uniprot ID: |
TPOR_HUMAN |
| Immunogen Region: |
Gln26-Trp491 |
| Immunogen: |
Recombinant Human Thrombopoietin R/MPL Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Trp491) of human Thrombopoietin R/MPL (Accession #NP_005364.1) fused with a 6×His tag at the C-terminus |
| Post Translational Modifications | Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination. |
| Function | Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. |
| Protein Name | Thrombopoietin ReceptorTpo-RMyeloproliferative Leukemia ProteinProto-Oncogene C-MplCd Antigen Cd110 |
| Database Links | Reactome: R-HSA-76009 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusCell Surface |
| Alternative Protein Names | Thrombopoietin Receptor proteinTpo-R proteinMyeloproliferative Leukemia Protein proteinProto-Oncogene C-Mpl proteinCd Antigen Cd110 proteinMPL proteinTPOR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
