| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.070ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This PPP2R4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
PTPA |
| Gene ID: |
5524 |
| Uniprot ID: |
PTPA_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis.the function appears to be independent from PP2A. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a ActivatorPp2a - Subunit B' - Pr53 IsoformPhosphotyrosyl Phosphatase ActivatorPtpaSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative ELISA Names | Serine/Threonine-Protein Phosphatase 2a Activator ELISA kitPp2a - Subunit B' - Pr53 Isoform ELISA kitPhosphotyrosyl Phosphatase Activator ELISA kitPtpa ELISA kitSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4 ELISA kitSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' ELISA kitPTPA ELISA kitPPP2R4 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
