| Post Translational Modifications | Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome. |
| Function | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. |
| Protein Name | Pcna-Associated FactorHepatitis C Virus Ns5a-Transactivated Protein 9Hcv Ns5a-Transactivated Protein 9Overexpressed In Anaplastic Thyroid Carcinoma 1Oeatc-1Pcna-Associated Factor Of 15 KdaPaf15P15pafPcna-Clamp-Associated Factor |
| Database Links | Reactome: R-HSA-5656169 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionFollowing Dna DamageLocalizes To Dna Damage SitesColocalizes With Centrosomes In Perinuclear Region |
| Alternative Protein Names | Pcna-Associated Factor proteinHepatitis C Virus Ns5a-Transactivated Protein 9 proteinHcv Ns5a-Transactivated Protein 9 proteinOverexpressed In Anaplastic Thyroid Carcinoma 1 proteinOeatc-1 proteinPcna-Associated Factor Of 15 Kda proteinPaf15 proteinP15paf proteinPcna-Clamp-Associated Factor proteinPCLAF proteinKIAA0101 proteinNS5ATP9 proteinPAF proteinL5 protein |
Information sourced from Uniprot.org
