Human NAAA protein (Recombinant) (N-His) (STJP005144)

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STJP005144
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NAAA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NAAA
Gene ID: 27163
Uniprot ID: NAAA_HUMAN
Immunogen Region: Ser29-Phe125
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine. A disulfide bond is seen in the crystal structure of the human protein, but the Cys residues are not conserved in rodents. Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (Probable).
Function Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.
Protein Name N-Acylethanolamine-Hydrolyzing Acid Amidase
Acid Ceramidase-Like Protein
Acylsphingosine Deacylase Naaa
N-Acylsphingosine Amidohydrolase-Like
Asah-Like Protein Cleaved Into - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Alpha - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Beta
Database Links Reactome: R-HSA-112310
Cellular Localisation Lysosome
Membrane
Peripheral Membrane Protein
Alternative Protein Names N-Acylethanolamine-Hydrolyzing Acid Amidase protein
Acid Ceramidase-Like Protein protein
Acylsphingosine Deacylase Naaa protein
N-Acylsphingosine Amidohydrolase-Like protein
Asah-Like Protein Cleaved Into - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Alpha - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Beta protein
NAAA protein
ASAHL protein
PLT protein

Information sourced from Uniprot.org

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