| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.056ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This MTDH Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
MTDH |
| Gene ID: |
92140 |
| Uniprot ID: |
LYRIC_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. |
| Post Translational Modifications | |
| Function | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. |
| Protein Name | Protein Lyric3d3/LyricAstrocyte Elevated Gene-1 ProteinAeg-1Lysine-Rich Ceacam1 Co-Isolated ProteinMetadherinMetastasis Adhesion Protein |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneCell JunctionTight JunctionNucleusNucleolusCytoplasmPerinuclear RegionIn Epithelial CellsRecruited To Tight Junctions (Tj) During The Maturation Of The Tj ComplexesA Nucleolar Staining May Be Due To Nuclear Targeting Of An Isoform Lacking The Transmembrane DomainTnf-Alpha Causes Translocation From The Cytoplasm To The Nucleus |
| Alternative ELISA Names | Protein Lyric ELISA kit3d3/Lyric ELISA kitAstrocyte Elevated Gene-1 Protein ELISA kitAeg-1 ELISA kitLysine-Rich Ceacam1 Co-Isolated Protein ELISA kitMetadherin ELISA kitMetastasis Adhesion Protein ELISA kitMTDH ELISA kitAEG1 ELISA kitLYRIC ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
