• Human MTDH (Metadherin) Sandwich ELISA Kit Ready-To-Use (STJE0017147)

Human MTDH (Metadherin) Sandwich ELISA Kit Ready-To-Use (STJE0017147)

SKU:
STJE0017147

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This MTDH Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: MTDH
Gene ID: 92140
Uniprot ID: LYRIC_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Post Translational Modifications
Function Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Protein Name Protein Lyric
3d3/Lyric
Astrocyte Elevated Gene-1 Protein
Aeg-1
Lysine-Rich Ceacam1 Co-Isolated Protein
Metadherin
Metastasis Adhesion Protein
Database Links
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Nucleus Membrane
Cell Junction
Tight Junction
Nucleus
Nucleolus
Cytoplasm
Perinuclear Region
In Epithelial Cells
Recruited To Tight Junctions (Tj) During The Maturation Of The Tj Complexes
A Nucleolar Staining May Be Due To Nuclear Targeting Of An Isoform Lacking The Transmembrane Domain
Tnf-Alpha Causes Translocation From The Cytoplasm To The Nucleus
Alternative ELISA Names Protein Lyric ELISA kit
3d3/Lyric ELISA kit
Astrocyte Elevated Gene-1 Protein ELISA kit
Aeg-1 ELISA kit
Lysine-Rich Ceacam1 Co-Isolated Protein ELISA kit
Metadherin ELISA kit
Metastasis Adhesion Protein ELISA kit
MTDH ELISA kit
AEG1 ELISA kit
LYRIC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance