Human LYVE1 protein (Recombinant-Active) (C-His) (STJP012332)

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STJP012332-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human LYVE1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: LYVE1
Gene ID: 10894
Uniprot ID: LYVE1_HUMAN
Immunogen Region: Ser24-Thr238
Immunogen: Homo sapiens (Human)
Post Translational Modifications O-glycosylated.
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium.
Protein Name Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1
Lyve-1
Cell Surface Retention Sequence-Binding Protein 1
Crsbp-1
Extracellular Link Domain-Containing Protein 1
Hyaluronic Acid Receptor
Database Links Reactome: R-HSA-2160916
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Localized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal Compartments
Undergoes Ligand-Dependent Internalization And Recycling At The Cell Surface
Localizes At Cell-Cell Junctions
Alternative Protein Names Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 protein
Lyve-1 protein
Cell Surface Retention Sequence-Binding Protein 1 protein
Crsbp-1 protein
Extracellular Link Domain-Containing Protein 1 protein
Hyaluronic Acid Receptor protein
LYVE1 protein
CRSBP1 protein
HAR protein
XLKD1 protein
UNQ230 protein
PRO263 protein

Information sourced from Uniprot.org

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