Post Translational Modifications | A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. |
Function | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. |
Protein Name | Keratin - Type I Cytoskeletal 14Cytokeratin-14Ck-14Keratin-14K14 |
Database Links | Reactome: R-HSA-446107Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
Cellular Localisation | CytoplasmNucleusExpressed In Both As A Filamentous Pattern |
Alternative Protein Names | Keratin - Type I Cytoskeletal 14 proteinCytokeratin-14 proteinCk-14 proteinKeratin-14 proteinK14 proteinKRT14 protein |
Information sourced from Uniprot.org