| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL-15RA/CD215-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications. |
| Conjugation: |
Biotin |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
| Gene Symbol: |
IL15RA |
| Gene ID: |
3601 |
| Uniprot ID: |
I15RA_HUMAN |
| Immunogen Region: |
Ile31-Thr205 |
| Immunogen: |
Recombinant Biotinylated Human IL-15RA/IL-15 R alpha/CD215 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.；It contains Ile31-Thr205. |
| Post Translational Modifications | N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor. |
| Function | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15. |
| Protein Name | Interleukin-15 Receptor Subunit AlphaIl-15 Receptor Subunit AlphaIl-15r-AlphaIl-15raCd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit AlphaSil-15 Receptor Subunit AlphaSil-15r-AlphaSil-15ra |
| Database Links | Reactome: R-HSA-8983432 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinNucleus MembraneCell SurfaceMainly Found Associated With The Nuclear MembraneIsoform 5: Endoplasmic Reticulum MembraneGolgi Apparatus MembraneCytoplasmic Vesicle MembraneIsoform 5Isoform 6Isoform 7 And Isoform 8 Are Associated With Endoplasmic ReticulumGolgi And Cytoplasmic VesiclesBut Not With The Nuclear MembraneIsoform 6: Endoplasmic Reticulum MembraneIsoform 7: Endoplasmic Reticulum MembraneIsoform 8: Endoplasmic Reticulum MembraneSoluble Interleukin-15 Receptor Subunit Alpha: SecretedExtracellular Space |
| Alternative Protein Names | Interleukin-15 Receptor Subunit Alpha proteinIl-15 Receptor Subunit Alpha proteinIl-15r-Alpha proteinIl-15ra proteinCd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha proteinSil-15 Receptor Subunit Alpha proteinSil-15r-Alpha proteinSil-15ra proteinIL15RA protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
