| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). |
| Protein Name | Cytochrome P450 1a1Cypia1Cytochrome P450 Form 6Cytochrome P450-CCytochrome P450-P1Hydroperoxy Icosatetraenoate Dehydratase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-211981Reactome: R-HSA-2142670Reactome: R-HSA-2142816Reactome: R-HSA-9018681 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMitochondrion Inner MembraneMicrosome MembraneCytoplasm |
| Alternative Protein Names | Cytochrome P450 1a1 proteinCypia1 proteinCytochrome P450 Form 6 proteinCytochrome P450-C proteinCytochrome P450-P1 proteinHydroperoxy Icosatetraenoate Dehydratase proteinCYP1A1 protein |
Information sourced from Uniprot.org
