| Function | Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. |
| Protein Name | Ctd Small Phosphatase-Like ProteinCtdsp-LikeCarboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3Nif-Like ProteinNuclear Lim Interactor-Interacting Factor 1Nli-Interacting Factor 1Protein Ya22Hya22Rbsp3Small C-Terminal Domain Phosphatase 3Scp3Small Ctd Phosphatase 3 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Ctd Small Phosphatase-Like Protein proteinCtdsp-Like proteinCarboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3 proteinNif-Like Protein proteinNuclear Lim Interactor-Interacting Factor 1 proteinNli-Interacting Factor 1 proteinProtein Ya22 proteinHya22 proteinRbsp3 proteinSmall C-Terminal Domain Phosphatase 3 proteinScp3 proteinSmall Ctd Phosphatase 3 proteinCTDSPL proteinC3orf8 proteinNIF1 proteinNIFL proteinSCP3 proteinYA22 protein |
Information sourced from Uniprot.org
