| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CSF-1/M-CSF-NO-tag protein was developed from hek293 cells and has a target region of NO-tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
＜1EU/Mu g |
| Immunoreactivity: |
Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 3.8-15.2 ng/mL, corresponding to a specific activity of 6.58×104~2.63×105 units/mg. |
| Gene Symbol: |
CSF1 |
| Gene ID: |
1435 |
| Uniprot ID: |
CSF1_HUMAN |
| Immunogen Region: |
Glu33-Arg255 |
| Immunogen: |
Recombinant Human CSF-1/M-CSF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu33-Arg255) of human CSF-1/M-CSF (Accession #NP_000748.3) fused with no additional amino acid. |
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Protein Name | Macrophage Colony-Stimulating Factor 1Csf-1M-CsfMcsfLanimostimProteoglycan Macrophage Colony-Stimulating FactorPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8957275Reactome: R-HSA-9680350 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinProcessed Macrophage Colony-Stimulating Factor 1: SecretedExtracellular Space |
| Alternative Protein Names | Macrophage Colony-Stimulating Factor 1 proteinCsf-1 proteinM-Csf proteinMcsf proteinLanimostim proteinProteoglycan Macrophage Colony-Stimulating Factor proteinPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit proteinCSF1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
