Human CD215/IL15RA protein (Recombinant) (C-Fc) (STJP007091)

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STJP007091
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD215/IL15RA-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL15RA
Gene ID: 3601
Uniprot ID: I15RA_HUMAN
Immunogen Region: Ile31-Thr205
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15.
Protein Name Interleukin-15 Receptor Subunit Alpha
Il-15 Receptor Subunit Alpha
Il-15r-Alpha
Il-15ra
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha
Sil-15 Receptor Subunit Alpha
Sil-15r-Alpha
Sil-15ra
Database Links Reactome: R-HSA-8983432
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus Membrane
Cell Surface
Mainly Found Associated With The Nuclear Membrane
Isoform 5: Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Cytoplasmic Vesicle Membrane
Isoform 5
Isoform 6
Isoform 7 And Isoform 8 Are Associated With Endoplasmic Reticulum
Golgi And Cytoplasmic Vesicles
But Not With The Nuclear Membrane
Isoform 6: Endoplasmic Reticulum Membrane
Isoform 7: Endoplasmic Reticulum Membrane
Isoform 8: Endoplasmic Reticulum Membrane
Soluble Interleukin-15 Receptor Subunit Alpha: Secreted
Extracellular Space
Alternative Protein Names Interleukin-15 Receptor Subunit Alpha protein
Il-15 Receptor Subunit Alpha protein
Il-15r-Alpha protein
Il-15ra protein
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha protein
Sil-15 Receptor Subunit Alpha protein
Sil-15r-Alpha protein
Sil-15ra protein
IL15RA protein

Information sourced from Uniprot.org

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