| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CPE |
| Gene ID: | 1363 |
| Uniprot ID: | CBPE_HUMAN |
| Immunogen: | Recombinant Human Carboxypeptidase E/CPE Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ser 453) of human Carboxypeptidase E (Accession #NP_001864) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | MAGRGGSALLALCGALAACG WLLGAEAQEPGAPAAGMRRR RRLQQEDGISFEYHRYPELR EALVSVWLQCTAISRIYTVG RSFEGRELLVIELSDNPGVH EPGEPEFKYIGNMHGNEAVG RELLIFLAQYLCNEYQKGNE TIVNLIHSTRIHIMPSLNPD GFEKAASQPGELKDWFVGRS NAQGIDLNRNFPDLDRIVYV NEKEGGPNNHLLKNMKKIVD QNTKLAPETKAVIHWIMDI |
| Function | Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. |
| Protein Name | Carboxypeptidase ECpeCarboxypeptidase HCphEnkephalin ConvertaseProhormone-Processing Carboxypeptidase |
| Database Links | Reactome: R-HSA-264876 |
| Cellular Localisation | Isoform 1: Cytoplasmic VesicleSecretory VesicleCytoplasmic VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Lipid Rafts In Intragranular Conditions |
| Alternative Protein Names | Carboxypeptidase E proteinCpe proteinCarboxypeptidase H proteinCph proteinEnkephalin Convertase proteinProhormone-Processing Carboxypeptidase proteinCPE protein |
Information sourced from Uniprot.org