| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Calsyntenin-1/CLSTN1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLSTN1 |
| Gene ID: |
22883 |
| Uniprot ID: |
CSTN1_HUMAN |
| Immunogen Region: |
Ala29-Thr859 |
| Immunogen: |
Recombinant Human Calsyntenin-1/CLSTN1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala29-Thr859) of human Calsyntenin-1/CLSTN1 (Accession #NP_001009566.1) fused with a 6×His tag at the C-termi |
| Post Translational Modifications | Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. Soluble Alc-alpha: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. CTF1-alpha: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. |
| Protein Name | Calsyntenin-1Alcadein-AlphaAlc-AlphaAlzheimer-Related Cadherin-Like ProteinNon-Classical Cadherin Xb31alpha Cleaved Into - Soluble Alc-AlphaSalc-Alpha - Ctf1-AlphaC-Terminal Fragment 1-Alpha |
| Cellular Localisation | Postsynaptic Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionNeuron ProjectionLocalized In The Postsynaptic Membrane Of Both Excitatory And Inhibitory SynapsesSoluble Alc-Alpha: NucleusThe Alcicd Fragment Is Translocated To The Nucleus Upon Interaction With Apbb1 |
| Alternative Protein Names | Calsyntenin-1 proteinAlcadein-Alpha proteinAlc-Alpha proteinAlzheimer-Related Cadherin-Like Protein proteinNon-Classical Cadherin Xb31alpha Cleaved Into - Soluble Alc-Alpha proteinSalc-Alpha - Ctf1-Alpha proteinC-Terminal Fragment 1-Alpha proteinCLSTN1 proteinCS1 proteinKIAA0911 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
