| Function | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity. May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity. |
| Protein Name | Calcium-Transporting Atpase Type 2c Member 1Atpase 2c1Atp-Dependent Ca(2+ Pump Pmr1Ca(2+/Mn(2+-Atpase 2c1Secretory Pathway Ca(2+-Transporting Atpase Type 1Spca1 |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinGolgi Stack MembraneDuring Neuron DifferentiationShifts From Juxtanuclear Golgi Position To Multiple Golgi Structures Distributed Over The Neural Soma With A Predominance In The Apical Dendritic Trunk |
| Alternative Protein Names | Calcium-Transporting Atpase Type 2c Member 1 proteinAtpase 2c1 proteinAtp-Dependent Ca(2+ Pump Pmr1 proteinCa(2+/Mn(2+-Atpase 2c1 proteinSecretory Pathway Ca(2+-Transporting Atpase Type 1 proteinSpca1 proteinATP2C1 proteinKIAA1347 proteinPMR1L proteinHUSSY-28 protein |
Information sourced from Uniprot.org
