| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.118ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This APLP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
APLP1 |
| Gene ID: |
333 |
| Uniprot ID: |
APLP1_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). |
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1Amyloid BetaA4 Precursor-Like Protein 1Amyloid-Like Protein 1AplpAplp-1 Cleaved Into - C30 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinC30: CytoplasmC-Terminally Processed In The Golgi Complex |
| Alternative ELISA Names | Amyloid Beta Precursor Like Protein 1 ELISA kitAmyloid Beta ELISA kitA4 Precursor-Like Protein 1 ELISA kitAmyloid-Like Protein 1 ELISA kitAplp ELISA kitAplp-1 Cleaved Into - C30 ELISA kitAPLP1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
