BMP1 Positive Control for STJ500266 peptide (STJ503745)

SKU:
STJ503745-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: BMP1 Positive Control for STJ500266 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: BMP1
Gene ID: 649
Uniprot ID: BMP1_HUMAN
Specificity: This is positive control is recommended for use in combination with BMP1 antibody STJ500266.
Tissue Specificity Ubiquitous.
Post Translational Modifications Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Peptide Name Bone Morphogenetic Protein 1
Bmp-1
Mammalian Tolloid Protein
Mtld
Procollagen C-Proteinase
Pcp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-1650814
Reactome: R-HSA-2214320
Reactome: R-HSA-2243919
Reactome: R-HSA-8963896 P13497-3
Cellular Localisation Golgi Apparatus
Trans-Golgi Network
Secreted
Extracellular Space
Extracellular Matrix
Co-Localizes With Postn In The Golgi
Isoform Bmp1-3: Secreted
Alternative Peptide Names Bone Morphogenetic Protein 1 protein
Bmp-1 protein
Mammalian Tolloid Protein protein
Mtld protein
Procollagen C-Proteinase protein
Pcp protein
BMP1 protein
PCOLC protein

Information sourced from Uniprot.org

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