Trial size DNM1L antibodies available in the Antibody Validation Project

Posted by M.Popov on 12th Nov 2020

Trial size DNM1L antibodies available in the Antibody Validation Project

Trial size DNM1L antibodies available in the Antibody Validation Project

Introduction:

The Dynamin 1 like protein is the product of the DNM1L gene. This disease related protein serves an important role by mediating membrane fission, ensuring the survival of several types of postmitotic neurons and controlling mitochondrial ATP production. The DNM1L protein can be found in several human tissues and mutations or disfunctions of its gene lead to mental disorders, cancers and lethal encephalopathy. We provide a number of trial sized antibodies, which are suitable for DNM1L research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding DNM1L that we have provided in the links below.

What is DNM1L?

The protein encoded by the DNM1L gene functions in mitochondrial and peroxisomal division and mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Through its function in mitochondrial division, the DNM1L protein ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage and it is required for normal brain development, including that of cerebellum. This protein is required for programmed necrosis execution and the rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production.

Where is DNM1L found?

Inside the cell, DNM1L is primairly found in the cytosol and additionally in the vesicles, and it has granular cytoplasmic and membranous expression in several tissues.

What role does DNM1L play in disease?

Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease and mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission 

DNM1L antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target DNM1L , which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed DNM1L antibodies

ModelNameHostClonalityRatingApplication Tested
STJ92779Anti-DRP1 antibodyRabbitPolyclonal5WB

Other DNM1L antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ91001Anti-Phospho-DRP1 (S637) antibodyRabbitPolyclonalELISA,IHC,WB
ModelNameHostClonalityRecommended Applications
STJ111011Anti-DNM1L AntibodyRabbitPolyclonalWB
STJ117910Anti-Phospho-DNM1L-(S637) AntibodyRabbitPolyclonalWB
STJ119079Anti-DNM1L AntibodyRabbitPolyclonalWB,IF
STJ119291Anti-DNM1L AntibodyRabbitPolyclonalWB,IF
STJ23408Anti-DNM1L AntibodyRabbitPolyclonalWB,IF,IP
STJ23409Anti-DNM1L AntibodyRabbitPolyclonalWB,IHC,IF

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.