| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNF423 (220-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF423 |
| Gene ID: |
23090 |
| Uniprot ID: |
ZN423_HUMAN |
| Immunogen Region: |
220-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-450 of human ZNF423 (NP_055884.2). |
| Immunogen Sequence: |
KPFKCTVCKRGFSSTSSLQS HMQAHKKNKEHLAKSEKEAK KDDFMCDYCEDTFSQTEELE KHVLTRHPQLSEKADLQCIH CPEVFVDENTLLAHIHQAHA NQKHKCPMCPEQFSSVEGVY CHLDSHRQPDSSNHSVSPDP VLGSVASMSSATPDSSASVE RGSTPDSTLKPLRGQKKMRD DGQGWTKVVYSCPYCSKRDF NSLAVLEIHLKTIHADKPQQ SHTCQICLDSM |
| Tissue Specificity | Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum. |
| Function | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation.this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
| Protein Name | Zinc Finger Protein 423Olf1/Ebf-Associated Zinc Finger ProteinHoazSmad- And Olf-Interacting Zinc Finger Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 423 antibodyAnti-Olf1/Ebf-Associated Zinc Finger Protein antibodyAnti-Hoaz antibodyAnti-Smad- And Olf-Interacting Zinc Finger Protein antibodyAnti-ZNF423 antibodyAnti-KIAA0760 antibodyAnti-NPHP14 antibodyAnti-OAZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
