• Western blot analysis of extracts of NCI-H460 cells, using VEGFD antibody (STJ23665) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-VEGFD antibody (20-220) (STJ23665)

SKU:
STJ23665

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FIGF (20-220) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VEGFD
Gene ID: 2277
Uniprot ID: VEGFD_HUMAN
Immunogen Region: 20-220
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human VEGF-D (NP_004460.1).
Immunogen Sequence: QGSSNEHGPVKRSSQSTLER SEQQIRAASSLEELLRITHS EDWKLWRCRLRLKSFTSMDS RSASHRSTRFAATFYDIETL KVIDEEWQRTQCSPRETCVE VASELGKSTNTFFKPPCVNV FRCGGCCNEESLICMNTSTS YISKQLFEISVPLTSVPELV PVKVANHTGCKCLPTAPRHP YSIIRRSIQIPEEDRCSHSK K
Tissue Specificity Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
Post Translational Modifications Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Function Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Protein Name Vascular Endothelial Growth Factor D
Vegf-D
C-Fos-Induced Growth Factor
Figf
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-194313
Reactome: R-HSA-195399
Cellular Localisation Secreted
Alternative Antibody Names Anti-Vascular Endothelial Growth Factor D antibody
Anti-Vegf-D antibody
Anti-C-Fos-Induced Growth Factor antibody
Anti-Figf antibody
Anti-VEGFD antibody
Anti-FIGF antibody

Information sourced from Uniprot.org

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