| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZIC2 |
| Gene ID: |
7546 |
| Uniprot ID: |
ZIC2_HUMAN |
| Immunogen Region: |
1-220 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2). |
| Immunogen Sequence: |
MLLDAGPQFPAIGVGSFARH HHHSAAAAAAAAAEMQDREL SLAAAQNGFVDSAAAHMGAF KLNPGAHELSPGQSSAFTSQ GPGAYPGSAAAAAAAAALGP HAAHVGSYSGPPFNSTRDFL FRSRGFGDSAPGGGQHGLFG PGAGGLHHAHSDAQGHLLFP GLPEQHGPHGSQNVLNGQMR LGLPGEVFGRSEQYRQVASP RTDPYSAAQLHNQYGPMNMN |
| Post Translational Modifications | Phosphorylated. Ubiquitinated by RNF180, leading to its degradation. |
| Function | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. |
| Protein Name | Zinc Finger Protein Zic 2Zinc Finger Protein Of The Cerebellum 2 |
| Database Links | Reactome: R-HSA-9823739 |
| Cellular Localisation | NucleusCytoplasmLocalizes In The Cytoplasm In Presence Of Mdfic OverexpressionBoth Phosphorylated And Unphosphorylated Forms Are Localized In The Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zic 2 antibodyAnti-Zinc Finger Protein Of The Cerebellum 2 antibodyAnti-ZIC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
