| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZFYVE1 (500-735) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZFYVE1 |
| Gene ID: |
53349 |
| Uniprot ID: |
ZFYV1_HUMAN |
| Immunogen Region: |
500-735 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 500-735 of human ZFYVE1 (NP_067083.1). |
| Immunogen Sequence: |
AKYAWSGYVIECPNCGVVYR SRQYWFGNQDPVDTVVRTEI VHVWPGTDGFLKDNNNAAQR LLDGMNFMAQSVSELSLGPT KAVTSWLTDQIAPAYWRPNS QILSCNKCATSFKDNDTKHH CRACGEGFCDSCSSKTRPVP ERGWGPAPVRVCDNCYEARN VQLAVTEAQVDDEGGTLIAR KVGEAVQNTLGAVVTAIDIP LGLVKDAARPAYWVPDHEIL HCHNCRKEFSIKLSKH |
| Tissue Specificity | Isoform 2: Highly expressed in heart. Also detected in the testis. Isoform 1: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart. |
| Function | Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication. |
| Protein Name | Zinc Finger Fyve Domain-Containing Protein 1Double Fyve-Containing Protein 1Sr3Tandem Fyve Fingers-1 |
| Cellular Localisation | Golgi ApparatusGolgi StackEndoplasmic ReticulumLipid DropletPreautophagosomal StructureMitochondrionResides Predominantly In The Cisternal Stacks Of The GolgiColocalizes With Trim13 On The Perinuclear Endoplasmic ReticulumDuring Starvation ConditionsLocalizes To Omegasomes Which Are Endoplasmic Reticulum Connected Strutures At The Origin Of Preautophagosomal StructuresLocalizes To Lipid Droplets In The Presence Of Oleic Acid |
| Alternative Antibody Names | Anti-Zinc Finger Fyve Domain-Containing Protein 1 antibodyAnti-Double Fyve-Containing Protein 1 antibodyAnti-Sr3 antibodyAnti-Tandem Fyve Fingers-1 antibodyAnti-ZFYVE1 antibodyAnti-DFCP1 antibodyAnti-KIAA1589 antibodyAnti-TAFF1 antibodyAnti-ZNFN2A1 antibodyAnti-PP10436 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
