| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc finger homeobox protein 3 (761-810 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZFHX3 |
| Gene ID: | 463 |
| Uniprot ID: | ZFHX3_HUMAN |
| Immunogen Region: | 761-810 aa |
| Specificity: | ATBF1 Polyclonal Antibody detects endogenous levels of ATBF1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ZFHX3 at the amino acid range 761-810 |
| Post Translational Modifications | Hyperphosphorylation protects ZFHX3 from calpain/CAPN1-mediated degradation. Ubiquitinated, leading to its proteasomal degradation. Nuclear localization is essential for its sumoylation. |
| Function | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells. |
| Protein Name | Zinc Finger Homeobox Protein 3 At Motif-Binding Factor 1 At-Binding Transcription Factor 1 Alpha-Fetoprotein Enhancer-Binding Protein Zinc Finger Homeodomain Protein 3 Zfh-3 |
| Database Links | Reactome: R-HSA-8941855 |
| Cellular Localisation | Nucleus Cytoplasm Translocates From The Cytoplasm To The Nucleus Following Tgf-Beta Stimulation Expressed In Nuclear Body (Nb)-Like Dots In The Nucleus Some Of Which Overlap Or Closely Associate With Pml Body |
| Alternative Antibody Names | Anti-Zinc Finger Homeobox Protein 3 antibody Anti-At Motif-Binding Factor 1 antibody Anti-At-Binding Transcription Factor 1 antibody Anti-Alpha-Fetoprotein Enhancer-Binding Protein antibody Anti-Zinc Finger Homeodomain Protein 3 antibody Anti-Zfh-3 antibody Anti-ZFHX3 antibody Anti-ATBF1 antibody Anti-C16orf47 antibody |
Information sourced from Uniprot.org