| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZFAND5 (40-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZFAND5 |
| Gene ID: |
7763 |
| Uniprot ID: |
ZFAN5_HUMAN |
| Immunogen Region: |
40-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human ZFAND5 (NP_001095890.1). |
| Immunogen Sequence: |
RQQNSGRMSPMGTASGSNSP TSDSASVQRADTSLNNCEGA AGSTSEKSRNVPVAALPVTQ QMTEMSISREDKITTPKTEV SEPVVTQPSPSVSQPSTSQS EEKAPELPKPK |
| Tissue Specificity | Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). |
| Function | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
| Protein Name | An1-Type Zinc Finger Protein 5Zinc Finger A20 Domain-Containing Protein 2Zinc Finger Protein 216 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-An1-Type Zinc Finger Protein 5 antibodyAnti-Zinc Finger A20 Domain-Containing Protein 2 antibodyAnti-Zinc Finger Protein 216 antibodyAnti-ZFAND5 antibodyAnti-ZA20D2 antibodyAnti-ZNF216 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
